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In Head-to-Head Matchup with KRd, VRd Remains Gold Standard of Care in Multiple Myeloma

The three-drug combination of bortezomib, lenalidomide, and dexamethasone (VRd) has been the standard therapy for patients with newly diagnosed multiple myeloma. The ENDURANCE trial presented at ASCO was a head-to-head effort to determine whether adding the next-generation proteasome inhibitor on the block, carfilzomib, to lenalidomide and dexamethasone (KRd) might perform even better. In short, it didn't.

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CAR T-Cell Therapy Produces ‘Remarkable’ Results in Multiple Myeloma, but It’s Still Not a Cure

Chimeric antigen receptor (CAR) T-cell therapy is showing great promise in multiple myeloma, as evidenced by a trio of investigational therapies presented at this year's ASCO conference. 

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What COVID-19 May Have Changed Forever About Multiple Myeloma Care — Telemedicine

COVID made oncologists rethink how to deliver care to their multiple myeloma patients, who are already at higher risk for infection. Providers increasingly shifted to telemedicine, and quickly realized its long-term benefits -- particularly for patients living far from major cancer centers.

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Selinexor Combo Effective For Relapsed Multiple Myeloma; Could it Benefit COVID Patients, Too?

Most multiple myeloma patients eventually relapse and their cancers become unresponsive to therapy, leaving them with limited remaining options and a poor prognosis. For these patients, the combination of selinexor plus dexamethasone represents a "critical new direction" in treatment.

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Could Ibrutinib Combined With Other Targeted Therapies and Chemo Be ‘the Future’ of B-Cell Lymphoma Treatment?

New research is enhancing our understanding of ibrutinib -- a Bruton's tyrosine kinase (BTK) inhibitor used to treat several different types of lymphoma, including chronic lymphocytic leukemia (CLL), small lymphocytic leukemia (SLL), and mantle cell lymphoma. It has also produced positive responses in B-cell lymphoma, but is so far only used in patients with relapsed/refractory disease.

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Brentuximab Vedotin is ‘Great Stride’ Toward Improving Lymphoma Outcomes

Brentuximab vedotin has added considerably to the lymphoma treatment options available to oncologists. The drug was initially approved for the treatment of relapsed Hodgkin's lymphoma following a stem cell transplant or, in patients who could not have a transplant, for those who had already undergone two or more chemotherapy treatments.

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Bispecific Antibodies Offer Lymphoma Patients a Promising New Therapeutic Option

Bispecific antibodies have exciting potential as a cancer therapy, due to their ability to simultaneously bind to two targets. Right now, this treatment is only available in investigational trials, but it has shown promising outcomes for patients with relapsed-refractory lymphoma who have already undergone a transplant, CAR T-cell therapy, or other lines of treatment.

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Overcoming Racial Disparities in Multiple Myeloma Research and Care

Multiple myeloma has one of the most dramatic racial disparities of any cancers. Black Americans are more than twice as likely to get this cancer than white Americans. They're also more likely to die from multiple myeloma.

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