Addressing Racial Disparities in Health Care

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First Positive Trial in Early-Stage NSCLC in 15 Years, According to Dr. Patrick Forde

Osimertinib (brand name: TAGRISSO) significantly improves disease-free survival and reduces the risk of recurrence in patients with epidermal growth factor receptor (EGFR)-positive early-stage non-small cell lung cancer (NSCLC) following a gross total resection when compared to placebo. The ADAURA trial, published this past October in The New England Journal of Medicine, suggests that osimertinib is an effective adjuvant treatment after complete tumor resection.

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If You’ve Ever Worked in a Lab and Everyone Thought You Were Crazy, Here’s Some Inspiration from Nobel Laureate Jim Allison…

In 2018 Jim Allison, an immunology researcher at MD Anderson Cancer Center, won the Nobel Prize for Physiology of Medicine. The most prestigious recognition in the world was the result of years of painstaking research in immunology. His scientific contributions were seen as a breakthrough as he was the pioneer of a revolutionary cancer treatment called CTLA-4 checkpoint inhibitor drugs.

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Black People are Dramatically Underrepresented in Clinical Trials

Black people have the highest death rates and shortest survival of any racial or ethnic group in the United States. Yet they are significantly underrepresented in studies evaluating the drugs that might improve their prognosis. A ProPublica analysis found that, in trials for 24 of the 31 cancer drugs approved between 2015 and 2018, less than 2% of participants were Black, even though Black Americans make up 13% of the population.

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What Physicians Can Do to Tackle Issues of Race in Cancer Screening and Treatment

Disparities in screenings among those with a family history of cancer are clearly documented in the medical literature. Still, little has changed in our practice to address them.

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Why Minorities Are Underrepresented in Clinical Trials and What Physicians Can Do About It

The idea that racial and ethnic minorities are underrepresented in clinical trials has been well documented. That disparity has meant that cancer therapies are not being tested in the full demographic of people who will one day make use of them in the clinical setting.

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New CAR T-Cell Therapy “Very Exciting” Because it Gives Patients One Year Without Progression

In September, the FDA accepted idecabtagene vicleucel (bb2121) for priority review. This investigational chimeric antigen receptor (CAR) T-cell immunotherapy is designed to treat patients with multiple myeloma who have received at least three previous therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody.

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Dexamethasone Use in Multiple Myeloma and COVID-19 Isn’t the Same

Corticosteroids such as hydrocortisone and dexamethasone have emerged as a valuable intervention to improve outcomes in critically ill patients with COVID-19. Randomized trials have indicated that these drugs reduce mortality in seriously ill patients receiving mechanical ventilation and supplemental oxygen.

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